Doctors long puzzled over the relationship

Corvallis, Oregon - Patients with HIV and other immune system disorders often suffer from poor absorption of food, leading to weight loss and malnutrition. Researchers from the University of Oregon have discovered the mechanism of intestinal failure BЂ "tripartite interaction between immune system and intestinal bacteria that live in the intestines. Opening of the genetic and cellular BЂњtrialogueBЂ "opens new possibilities for therapy upending some basic provisions in the fields of immunology, according, the new Associate in OSUBЂ ™ s

and author of the study. BЂњIn textbook of immunology, the immune system exists primarily to deal with harmful microbes, tumors, etc., BЂ "said Morgun. BЂњAny link between the immune system and metabolism beyond what are the side effects of lasix the standard paradigm in the field. The idea that the immune system is directly involved in the maintenance and regulation of metabolism is a new concept. BЂ "

The results were published in Nature Medicine, the journal. Doctors long puzzled over the relationship between lack of immunity and defective digestion. Scientists were unable to find the pathogen, which could explain the debilitating disease suffering patients. New World at this riddle shed in recent years, when immunologists discovered that intestine, called the epithelium, does more than simply absorb food. But the link between the immune and food metabolism remain unknown BЂ "so far. Morgun and his colleagues found that these two functions are not only related, but actually interact and regulate each other. When the epithelium shows loss of cell BЂ "white blood cells that fight infection BЂ" it moves to help the body compensate for the loss of immunity. BЂњIt launches its own defense mechanism, BЂ "Morgun wrote OSU researcher Professor Natalia Shulzhenko in Nature Medicine,

. After bowel assume this new role, she falls back on his usual work, absorbs fats and other nutrients in food. BЂњIf immune system act BЂ "they wrote, BЂњthe epithelium takes some missing immune function due to metabolic activity. BЂ "Without proper absorption of fat wasting occurs. Finding the keys to a trigger, they found a network of more than 225 genes that regulate metabolism and linked immunity in the intestine of mice and humans. These genes participate in the conversation BЂњcross, BЂ "every familiar that affect others. The authors characterize this trilateral talks between the epithelium, B cells and microorganisms that inhabit the intestine, as balancing. When a person varies, the balance board. These data are important for treatment that focused on anti-inflammatory drugs. Instead, researchers suggest shifting the focus of treatment on changes of epithelial cells in certain areas. Another promising area to investigate a possible link between epithelial cells and the activity of autoimmune diseases. Other authors on the study, conducted at the National Institute of Allergy and Infectious Diseases (NIAID), including Polly Matzinger of T-cell memory and tolerance Section Laboratory of Cell and Molecular Immunology (nicknamed BЂњGhost LabBЂ ") at NIAID. .